Yes! The Plugable USBC-NVME enclosure does support Trim with compatible operating systems and files systems.
For Windows, Trim support was initially added with Windows 7 for SATA SSDs, however support for USB Trim was not added until Windows 8 with the UAS (USB Attached SCSI) Protocol. Trim is supported on Microsoft's ReFS and NTFS file systems.
For macOS, Trim support was initially added with macOS 10.6.8, however Trim support was limited to Apple branded SSDs. As of macOS 10.10.4 the trimforce terminal command was added to support Trim on 3rd party SSDs. Some users have reported success with Trim on our USBC-NVME enclosure while others have reported the command failed to execute correctly. Apple's HFS+ and APFS file systems both support Trim.
For Linux, Trim support was added with kernel 2.6.28 and is compatible with a variety of file systems, default Trim behavior is dependent on the specific Linux distribution and version.